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William (Bill) Sheridan
Chester Fritz Distinguished Professor
Starcher Hall Room 301
Office Tel: 701.777.4479
B.S.A., 1958, University of Florida
M.S., 1960, University of Florida
Ph.D. 1965, University of Illinois
- Associate Editor, GENETICS
- Editor, MAIZE FOR BIOLOGICAL RESEARCH, a special publication of the Plant Molecular
- Biology Association
- Fellow of American Association for Advancement of Science
- Fulbright Award, Denmark 1977-1978
- Honorary Fellow, University of Minnesota, 1981-1982
- Visiting Professor, Purdue University, 1988
- Visiting Professor, University of Oregon 1988-1990
The research interests of my laboratory are in genetics and developmental biology. Current research involves the use of maize, a plant especially well suited for fundamental investigation since it is the best characterized flowering plant from a genetic point of view.
Genetic, morphological, structural, and molecular techniques are being used to pursue a greater understanding of plant development and the role of genes in this process.
A genetic dissection of embryo development is being done by characterizing a group of mutants that are blocked at different stages early in embryo development and by comparing them with normal embryos. We are especially interested in studying how genes are involved in the formation of the shoot apex and first leaf primordium, that is, how the mass of cells of the proembryo differentiates into specific structures arranged in precise patterns and the role of genes in this sequence.
We are also conducting a mutational analysis of maize meiosis in collaboration with Dr. Inna Golubovskaya of the Vavilov Plant Research Institute in St. Petersburg, Russia. In this research we are identifying and characterizing genes that control the commitment of cells to meiosis as well as the cellular events of the meiotic process. We are also conducting a mutational analysis of female gametophyte development in maize. In this study we are seeking to identify genes that control the development of the functional megaspore into the mature embryo sac.
Graduate students performing research in my laboratory learn how to plant, take care of and hand-pollinate maize, how to harvest and store it; how to make genetic crosses and analyze them to map genes; how to dissect our embryos from kernels and culture them on media and to fix and prepare them for light and electron microscopy; how to prepare media and perform various tissue culture techniques. We are initiating studies using recombinant DNA techniques for cloning and characterizing the genes of interest. These research activities provide the opportunity to acquire a broad range of techniques and knowledge in plant genetics and plant development biology.
For the past several years the research on the maize mutants has been sponsored by grants from the National Science Foundation (NSF) and is currently being supported by the Developmental Biology program at NSF.
Sheridan, W.F. 2011. Variable transmission of eight maize Activators (Ac) elements located on the short arm of chromosome 1. G3-Genes, Genomes and Genetics 1:259-261
Pawlowski, W.; Wang, C.; Golubovskaya, I., Szymaniak, J.M., Shi, L.; Hamant, O., Zhu, T., Harper, L., Sheridan, W.F.; and Cande, W.Z. 2009. Maize AMEIOTIC1 is essential for multiple early meiotic processes and likely required for the initiation of meiosis. PNAS 106: 3603-3608.
Sheridan, W. F. and D. L. Auger 2008. Chromosome segmental dosage analysis of maize morphogenesis using B-A-A translocations. Genetics 180:755-769.
Sheridan, W.F. and D.L. Auger, 2006. Construction and uses of new compound B-A-A maize chromosome translocations. Genetics 174: 1755-1765.
Pawlowski, W.; Golubovskaya, I.; Timofeeva; Meeley, R.B.; Sheridan, W.F.; and Cande, W.Z. 2004. Poor homologous synapsis 1: A Novel Gene Required for Homologous Chromosome Recognition in Meiosis. Science 303:89-92.
Auger, D.L. and W.F. Sheridan. 2001. Negative interference in maize translocation heterozygotes. Genetics 159:1717-1726.
V. Raboy, P.F. Gerbasi, K.A. Young, S.D. Stoneberg, S.G. Pickett, A.T. Bauman, P.P.N. Murthy, W.F. Sheridan and D.S. Ertl. 2000. Origin and Seed Phenotype of Maize low phytic acid 1-1 and low phytic acid 2-11. Plant Physiology 124:355-368
R. Elster, P. Bommert, W.F. Sheridan, W. Werr. 2000. Analysis of four embryo-specific mutants in Zea mays reveals that incomplete radial organization of the proembryo interferes with subsequent development. Dev. Genes. Evol. 210: 300-310.
T. Heckel, K. Werner, W.F. Sheridan, C. Dumas, P.M. Rogowsky. 1999. Novel phenotypes and developmental arrest in early embryo specific mutants of maize. Planta 210: 1-8.
Sheridan, W.F., E.A. Golubeva, L.I. Abramova, and I.N. Golubovskaya. 1999. The mac1 mutation alters the developmental fate of the hypodermal cells and their cellular progeny in the maize anther. Genetics 153: 933-941.
Huang, B.-Q. and W.F. Sheridan 1998. Actin coronas in normal and indeterminate gametophyte1 embryo sacs of maize. Sex. Plant. Reprod. 11: 257-264.
Sheridan, W.F. and B.-Q. Huang. 1997. Nuclear behavior is defective in the maize (Zea mays L.) lethal ovule2 female gametophyte. Plant Journal 11:1029-1041.
Golubovskaya, I.N.., Z.K. Grebennikova, D.L. Auger, and W..F. Sheridan. 1997. The maize desynaptic1 mutation disrupts meiotic chromosome synapsis. Develop. Genet. 21: 146-159.
Golubovskaya, I., N. Avalkina, and W.F. Sheridan 1997. New insights into the role of the maize ameiotic1 locus. Genetics 147:1339-1350.
Sheridan, W.F., N.A. Avalkina, I.I. Shamrov, T.B. Batygina, and I. Golubovskaya. 1996. The mac1 gene: controlling the commitment to the meiotic pathway in maize. Genetics 142: 1009-1020.
Huang, Bing-Quan and Sheridan, William F. 1996. Embryo sac development in the maize indeterminate gametophyte1 mutant: abnormal nuclear behavior and defective microtubule organization. Plant Cell 8:1391-1407.
Clark, J. K. and W. F. Sheridan. 1994. Allelism testing of lethal mutations. In: The Maize Handbook. pp. 407-413. M. Freeling and V. Walbot, eds. Springer-Verlag, New York. Sheridan, W.F. 1995. Genes and embryo morphogenesis in angiosperms. Develop. Genetics 16:291-297.
Auger, D. and W. F. Sheridan. 1994. Using cytogenetics to enhance transposon tagging with Ac throughout the maize genome. In: The Maize Handbook. pp. 234-239. M. Freeling and V. Walbot, eds. Springer-Verlag, New York.
Sheridan, W. F. and J. K. Clark. 1994. Fertilization and embryogeny in maize. In: The Maize Handbook. pp. 3-10. M. Freeling and V. Walbot. eds. Springer-Verlag, New York.
Huang, B.-Q. and W. F. Sheridan. 1994. Female gametophyte development in maize: Microtubular organization and embryo sac polarity. Plant Cell. 6:845-861.
Sheridan, W. F. and J. K. Clark. 1993. Mutational analysis of morphogenesis of the maize embryo. Plant Journal 3:347-358.
Birchler, J.A. and W. F. Sheridan. 1993. Evidence for induction of a B-A translocation involving the long and short arms of chromosome 10 in maize. Maydica 38:115-119.
Golubovskaya, I., Z. K. Grehennikova, N.A. Avalkina, and W. F. Sheridan. 1993. The role of the Ameiotic1 gene in the initiation of meiosis and in subsequent meiotic events in maize. Genetics 135:1151-1166.
Golubovskaya, I., N. A. Avalkina and W. F. Sheridan. 1992. Effects of several meiotic mutations on female meiosis in maize. Develop. Genetics 13:411-424.