Jefferson Vaughan

Professor

Medical Entomology & Arthropod-Transmitted Diseases

Starcher Hall Room 109

Office Tel: 701.777.2199

jefferson.vaughan@UND.edu

Education

B.S. Biology, 1977, Colorado State University

M.S. Entomology, 1982, Virginia Polytechnic Institute & State University

Ph.D. Entomology, 1985, Virginia Polytechnic Institute & State University

Post-Doctoral and Associate Research Affilations

• University of Maryland School of Medicine
• 1986-1989 Post-doctoral. Malaria & antibody passage in mosquitoes.
• 1996-1999 Visiting Assistant Professor. Flea physiology, spotted fever rickettsiae, ticks.
• Johns Hopkins School of Hygiene & Public Health
• 1990-1993 Research Associate. Malaria sporogony.
• 1995-1998 Research Associate. Microfilarial enhancement of arboviral transmission.
• U.S. Army Medical Research Institute of Infectious Diseases
• 1994-1998. Visiting Scientist. Parasitic enhancement of arboviral transmission.
• 2001 - present. Visiting Scientist. Microfilarial enhancement of dengue transmission.

Research Interests

Primary research interests center on the various insects and ticks that can transmit disease organisms to humans and wildlife. Specific interests center on:

1. Malaria parasite development within vector mosquitoes using a population dynamics approach.
2. Potential of filarial infections to enhance arboviral infection of mosquitoes.
3. The effects that host blood components, such as antibody or drugs, can exert on both vector arthropods and the growth characteristics of pathogens developing within vector arthropods.

Selected Publications

Malaria

Zollner GE, N Ponsa, GW Garman, S Poudel, JA Bell, J Sattabongkot, RE Coleman and JA Vaughan . 2006. Population dynamics of sporogony for Plasmodium vivax parasites from western Thailand developing within three species of colonized Anopheles mosquitoes. Malaria J. 5: e68.

Vaughan, JA , Scheller, LF, RA Wirtz and AF Azad 1999. Comparative infectivity of Plasmodium berghei sporozoites to mice when delivered by intravenous inoculation versus infectious mosquito bite: implications for sporozoite vaccine trials. Inf. Immun. 67: 4285-4289.

Vaughan JA , BH Noden and JC Beier. 1994. Sporogonic development of cultured Plasmodium falciparum in six species of laboratory-reared Anopheles mosquitoes. Am. J. Trop. Med. Hyg. 51: 233-243.

Vaughan JA , BH Noden and JC Beier. 1992. Population dynamics of Plasmodium falciparum sporogony in laboratory-infected Anopheles gambiae . J. Parasitol. 78: 716-724.

Arboviruses

Bell JA, CM Brewer, NJ Mickelson, GW Garman and JA Vaughan . 2006. West Nile virus epizootiology, central Red River valley, North Dakota and Minnesota, 2002-2005. Emerg. Infect. Dis. 12: 1245-1247.

Vaughan, JA , M Trpis and MJ Turell 1999. Brugia malayi microfilariae enhance the infectivity of Venezuelan equine encephalitis virus to Aedes mosquitoes. J. Med. Entomol. 36:758-763.

Vaughan, JA and MJ Turell. 1996. Dual host infections: enhanced infectivity of eastern equine encephalitis virus to Aedes mosquitoes mediated by Brugia microfilariae. Am. J. Trop. Med. Hyg. 54: 105-109.

Fate of host blood components in bloodsucking arthropods

Vaughan, JA , DE Sonenshine and AF Azad. 2002. Kinetics of ingested host immunoglobulin G in hemolymph and whole body homogenates during nymphal development of Dermacentor variabilis and Ixodes scapularis ticks (Acari: Ixodidae). Exp. Appl. Acarol. 27: 329-340.

Vaughan JA and AF Azad. 1993. Patterns of erythrocyte digestion by bloodsucking insects: constraints on vector competence. J. Med. Entomol. 30: 214-216.

Vaughan JA , BH Noden and JC Beier. 1991. Concentration of human erythrocytes by anopheline mosquitoes during feeding (Diptera: Culicidae). J. Med. Entomol. 28: 780-786.

Vaughan JA and AF Azad. 1988. Passage of host immunoglobulin G from bloodmeal into hemolymph of selected mosquito species. J. Med. Entomol. 25: 472-474.

Publications Since 2000

Noden BH, JA Vaughan, CB Pumpuni, and JC Beier. 2011. Mosquito ingestion of antibodies against mosquito midgut microbiota improves conversion of ookinetes to oocysts for Plasmodium falciparum, but not P. yoelii. Parasit. Internat. (in press).

Vaughan JA, DA Focks and MJ Turell. 2009. Simulation models examining the effect of Brugian filariasis on dengue epidemics. Am. J. Trop. Med. Hyg. 80: 44-50.

Tkach VV, SD Snyder and JA Vaughan. 2009. A new species of blood fluke (Digenea: Spirorchiidae) from the Malayan box turtle, Cuora ambionensis (Cryptodira: Geomydidae) in Thailand. J. Parasitol. 95: 743-746.

Poudel SK, RA Newman and JA Vaughan. 2008. Rodent Plasmodium: Population dynamics of early sporogony within Anopheles stephensi mosquitoes. J. Parasitol. 94: 999-1008.

Vaughan JA 2008. West Nile fever. In: Encyclopedia of Plagues, Pestilence and Pandemics. Greenwood Press, USA.

Vaughan JA 2007. Population dynamics of Plasmodium sporogony. Trends Parasitol. 23: 63-70.

Vaughan JA, JA Bell, MJ Turell and DD Chadee. 2007. Passage of ingested Mansonella ozzardi (Spirurida: Onchocercidae) microfilariae through the midgut of Aedes aegypti mosquitoes (Diptera: Culicidae). J. Med. Entomol. 44: 111-116

Coleman RE, J Sattabongkot, S Promstaporm, N Maneechai, B Tippayachai, A Kengluecha, N Rachapaew, G Zollner, RS Miller, JA Vaughan, K Thimasarn and B Khuntirat. 2006. Comparison of PCR and microscopy for the detection of asymptomatic malaria in a Plasmodium falciparum/vivax endemic area in Thailand. Malaria J. 5: 121-127.

Zollner GE, N Ponsa, GW Garman, S Poudel, JA Bell, J Sattabongkot, RE Coleman and JA Vaughan. 2006. Population dynamics of sporogony for Plasmodium vivax parasites from western Thailand developing within three species of colonized Anopheles mosquitoes. Malaria J. 5: 68-83.

Bell JA, CM Brewer, NJ Mickelson, GW Garman and JA Vaughan. 2006. West Nile virus epizootiology, central Red River valley, North Dakota and Minnesota, 2002-2005. Emerg. Infect. Dis. 12: 1245-1247.

Bell JA, NJ Mickelson, and JA Vaughan. 2005. West Nile virus in host-seeking mosquitoes within a residential neighborhood in Grand Forks, North Dakota. Vector-Borne and Zoonotic Dis. 5: 373-382.

Kuzmin Y, VV Tkach and JA Vaughan 2005 Rhadias kongmongthaensis sp. n. from Polypedates leucomystax (Amphibia, Anura, Rhacophoridae) in Thailand. Folia Parasitologica 52: 339-342.

Zollner GE, N Ponsa, RE Coleman, J Sattabongkot, and JA Vaughan. 2005. Efficacy of sampling techniques for determining absolute density of Plasmodium vivax ookinetes in Anopheles dirus mosquitoes. J. Parasitol. 91: 453-457.

Vaughan, JA, DE Sonenshine and AF Azad. 2002. Kinetics of ingested host immunoglobulin G in hemolymph and whole body homogenates during nymphal development of Dermacentor variabilis and Ixodes scapularis ticks (Acari: Ixodidae). Exp. Appl. Acarol. 27: 329-340.

Lal, A, PS Patterson, JB Sacci, JA Vaughan, C Paul, WE Collins, RA Wirtz, and AF Azad 2001. Anti-mosquito midgut antibodies block development of Plasmodium falciparum and Plasmodium vivax in multiple species of Anopheles mosquitoes and reduce vector fecundity and survivorship Proc. Nat. Acad. Sci. 98: 5228-5233.

Vaughan, JA. 2000. Which routes do Plasmodium sporozoites use for successful infections of vertebrates? (Letter to the Editor - Author's Reply). Infection and Immunity 68: 3064-3065.